Hi @Glenn Maxwell ,
First check if this a general network issue, see this: https://www.problogbooster.com/2015/03/fix-this-site-cannot-be-reached-err-connection-timed-out-reset-chrome-windows-error-dns-address-not-found-lookup-failure-localhost-refused-to-connect-solved.html. Or you can tell the issue user to change a computer or network environment to see if the issue still exists.
Second have a try to access OneDrive for business via App bar on the left upper corner instead of direct URL.
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