Hi @Declan Ridley ,
Please refer to the following steps to create a registry entry that excludes your Outlook to detect Office365 and see if it changes:
1.Locate this location in Registry Editor:
HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Outlook\AutoDiscover
2.Create a DWORD (30-bit) value for ExcludeExplicitO365Endpoint and change the value to "1" to enable it.
3.Restart the computer and log in to the Outlook client.
If you are still unable to connect to the exchange server after the above operations, please refer to this link to run Test Email AutoConfiguration .
Enable and collect logs for profile creation issues - Outlook | Microsoft Learn
If possible, please provide the screenshot about log page for our better research. (In order to avoid the disclosure of your privacy, please remember to hide your personal information).
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