Hello cf_tru_mmu,
What is the size of the payload? did you try a smaller payload size, just wanted to make sure if this is not the issue?
You can also refer to the Connect a Renesas RX65N Cloud Kit to Azure IoT Central quickstart for more information on how to connect a Renesas RX65N Cloud kit device to Azure IoT and send telemetry.
Community SME's on this topic or our team will review your scenario and circle back at the possible earliest time.