@Salah Ghalloussi, Thanks for posting in Q&A. For the Remote address setting, it only accepts some specific format value. If you want to block the inbound or outbound from one domain, you can enter the IP address or range of the domain you want to block.
https://video2.skills-academy.com/en-us/mem/intune/protect/endpoint-protection-windows-10#ip-address-settings
Hope the above information can help.
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