I found a case similar to your symptom description, you can try this method.
Also, how about trying the private mode or changing the browser?
I also found that it may be related to the pending server update, you can refer to Solution 2 in this link:
https://www.stellarinfo.com/blog/exchange-server-http-500-error-ecp/
(Please Note: Since the web site is not hosted by Microsoft, the link may change without notice. Microsoft does not guarantee the accuracy of this information.)
Regards
Shaofan
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