Its not enough to just set the connector.
You have to set the global org limits to 50GB for send and receive, set any connectors used to 50MB then set the mailbox itself as well:
https://video2.skills-academy.com/en-us/exchange/mail-flow/message-size-limits?view=exchserver-2019
If it just for one user, then create a transport rule that rejects messages larger than the current limit with an exception for this user.