Yes you can run a failover for VMs that are set up for disaster recovery to a secondary Azure region
Azure Site Recovery service may help you
if you need details Microsoft has official documentation for this purpose
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If your primary site goes offline and vm's have replication enabled, can you failover to the secondary site without primary online?
Yes you can run a failover for VMs that are set up for disaster recovery to a secondary Azure region
Azure Site Recovery service may help you
if you need details Microsoft has official documentation for this purpose