Hi,
Do you want to remove Office files cache?
Or you need to stop saving Office temporary files automatically?
For remove Office files cache, please refer to this support article:
If you enable auto-save, this feature will automatically generate temporary files. Temporary files are files that store information such as computing history, cached data, etc., to ensure the security and integrity of the data, as well as to be able to recover unsaved work in the event of an accident.
You can try disabling this feature, go to File- Options- Save- uncheck the AutoSave options:
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