You can create multiple user accounts on your Mac, each with different 365 settings. Using System Setting>Users & Groups, create a second user account on your Mac. Set up one account for your university sign-in and the other for your work setup. You can switch accounts without rebooting from the right end of the macOS menu bar.
How to have two microsoft accounts co-exist on Mac?
Olivia Lockrow
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I have a Microsoft account through my college, and my job recently switched over to have us sign in through a microsoft backed account. Now, on safari, I cannot access them both without clearing cookies every single time. This is a large issue, as I use both frequently. I do not understand why I cannot link them. Is there any way around this?? It's extremely frustrating to be unable to sign in to two important accounts.