Just make sure the ports are flowing between sites.
https://video2.skills-academy.com/en-us/troubleshoot/windows-server/identity/config-firewall-for-ad-domains-and-trusts
https://video2.skills-academy.com/en-us/exchange/plan-and-deploy/deployment-ref/network-ports?view=exchserver-2019
https://video2.skills-academy.com/en-us/troubleshoot/windows-server/networking/service-overview-and-network-port-requirements
https://www.microsoft.com/en-us/download/details.aspx?id=24009
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