Hello @Juan Pablo Delgadillo Martinez
Thank you for reaching out to the Microsoft Q&A platform
It depends which resource apps were selected in the CA policy. If they only applied the policy to the AVD apps, then it should not impact office. You will want to enable SSO for the connection so the MFA claims of the user can transfer into the session and meet your M365 MFA requirements.
Let me know if you have any queries.
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