Hi @NASH Martyn
Does anyone else have the same issue in your organization?
The following official document said that if you install the Microsoft .NET Framework Security Update MS16-065 on a Front End or Standard Edition server for Skype for Business 2015, the internal client cannot connect to conferencing modalities normally. You could try to check it and see if the workaround is helpful to you.
Moreover, please try to clear the Skype for Business client cache file by following these steps:
- Log out of Skype for Business
- Delete any sign-in information
- Exit Skype for Business
- Navigate to Users > [Your Username] > AppData > Local > Microsoft > Office > 15.0 > Lync
- Delete the sip_profileName folder
- Delete all files in Tracing folder. Do not delete the folder itself
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