@Rahul Sukumar Assuming you are referring to on-prem virtual machines, DPM or MABS doesn’t have integration with WAC yet.
But you can certainly use MABS or DPM to backup VMs stored on S2D cluster as Hyper-V VM.
https://video2.skills-academy.com/en-us/azure/backup/back-up-hyper-v-virtual-machines-mabs
Additional resources:
For DPM refer to https://video2.skills-academy.com/en-us/system-center/dpm/dpm-overview?view=sc-dpm-2019
MABS refer to: https://video2.skills-academy.com/en-us/azure/backup/backup-azure-microsoft-azure-backup
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