BizTalk Server 2020 supports .Net 4.7.2 and above, this means .NET 4.8 is fully supported.
For BizTalk 2020, is .Net 4.8 Supported?
Colin Dijkgraaf
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On the page Hardware and Software Requirements for BizTalk Server 2020 it has
Supported minimum version:
.NET Framework 4.7.2
But no maximum version, does that mean .Net Framework 4.8 is supported?
According to this blog BIZTALK AUTOMATED MIGRATION
Note – For BizTalk 2020 we found a bug with .Net Framework 4.7.2, so we decided to migrate all the projects to 4.8 version.
As per my own blog BizTalk supported Microsoft .Net Frameworks & August 2019 Windows Updates, there have been issues with BizTalk if you have an unsupported version of .Net installed.