Outlook 365 (C2R) Cannot Open Outlook OST cannot be accessed (2.9.7654.46150)

Craig Irvin 2 Reputation points
2021-05-06T18:20:22.043+00:00

Hello all I've reviewed all of the posts that I can in relation to OST issues and tried what I could from setting time out settings, disabling shared mailbox caching, AV exclusions, NTFS/Share permissions, making sure the profile disk isn't locked and so on.

My issue is that on a brand new profile being created we will consistently get the error "Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened. The file <file path> cannot be accessed. You must connect to Microsoft Exchange at least once before you can use your Outlook data file (.ost)."

If I delete the mapi profile and recreate the problem will still happen. Same with deleting the profile and trying again.

In some cases it works but once you log off and back on a few times.

If I remove the user from being allowed to use FSLogix none of this happens. So I'm kind of drawing a blank on what needs to be done. The one question I do have is I stumbled onto a post about having to reinstall Office once you install FSLogix. Is there any weight to this? Is there anything else that we can try?

FSLogix
FSLogix
A set of solutions that enhance, enable, and simplify non-persistent Windows computing environments and may also be used to create more portable computing sessions when using physical devices.
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  1. Craig Irvin 2 Reputation points
    2021-09-09T14:11:51.963+00:00

    Correction. I'm unable to open a support request using the methods that are outlined. We do not have an active SA agreement that provides support or Premier subscription. If I try to use the paid option I can enter in my credit card number but there is no button to submit it. I'm stuck and really do need help on this issue; more than willing to pay Microsoft for the assist.

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