Hi,
Have been excluding that folder for years, never had any complains from users.
This is the paths I exclude for Chrome
<Exclude Copy="0">AppData\Roaming\Chrome\PepperFlash</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\pnacl</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Default\Code Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Default\Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Default\GPUCache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Default\Application Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Default\IndexedDB</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Default\Service Worker\CacheStorage</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 1\Code Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 1\Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 1\GPUCache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 1\Application Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 1\IndexedDB</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 1\Service Worker\CacheStorage</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 2\Code Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 2\Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 2\GPUCache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 2\Application Cache</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 2\IndexedDB</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Profile 2\Service Worker\CacheStorage</Exclude>
<Exclude Copy="0">AppData\Roaming\Chrome\Snapshots</Exclude>